Piramal Pharma
40+ Interview Questions and Answers
Q1. What is the difference between discriminatory media & bio relevant media?
Discriminatory media is biased towards certain groups while bio relevant media mimics the natural environment of cells.
Discriminatory media can be based on race, gender, or other factors that unfairly favor or disadvantage certain groups
Bio relevant media is designed to replicate the conditions that cells would experience in the body, such as temperature, pH, and nutrient levels
Discriminatory media can lead to inaccurate or incomplete research results, while bio relevant medi...read more
Q2. How will you perform method precision for Related substances method?
Method precision for related substances method is performed by analyzing multiple samples of known concentration and calculating the standard deviation.
Analyze multiple samples of known concentration
Calculate the standard deviation
Ensure the precision is within acceptable limits
Repeat the analysis to confirm the precision
Use appropriate statistical tools to analyze the data
Q3. How you will improve the quality and productivity of products
To improve the quality and productivity of products, I would implement various strategies such as implementing quality control measures, optimizing production processes, and fostering a culture of continuous improvement.
Implementing quality control measures to identify and rectify any defects or issues in the production process.
Optimizing production processes by streamlining workflows, eliminating bottlenecks, and implementing automation where applicable.
Investing in employee...read more
Q4. What are the EU requirements for multimedia dissolution?
EU requirements for multimedia dissolution
Multimedia dissolution testing is required for certain types of drug products in the EU
The requirements are outlined in the European Pharmacopoeia (EP)
The EP specifies the apparatus, dissolution medium, and testing conditions for multimedia dissolution
The acceptance criteria for dissolution testing are also provided in the EP
Q5. What is GMP ?,what is change control system ?
GMP stands for Good Manufacturing Practice. Change control system is a process to manage changes in a controlled manner.
GMP is a set of guidelines that ensure the quality and safety of pharmaceutical products.
It covers all aspects of production, from raw materials to finished products.
Change control system is a process to manage changes in a controlled manner.
It involves documenting and reviewing proposed changes, assessing their impact, and implementing them in a controlled ...read more
Q6. How will you develop dissolution method?
I will develop dissolution method by considering the drug properties, selecting appropriate media, and optimizing parameters.
Understand the drug properties and solubility
Select appropriate media based on pH and solubility
Optimize parameters such as agitation speed and temperature
Validate the method by testing for accuracy and precision
Consider regulatory guidelines and requirements
Q7. 1. When system lose pressure then what are doing ? 2. How many types of Dissolution ?
Answering questions related to system pressure and types of dissolution.
When a system loses pressure, it needs to be re-pressurized to maintain its functionality.
There are two types of dissolution: intrinsic and extrinsic.
Intrinsic dissolution refers to the dissolution of a pure substance, while extrinsic dissolution refers to the dissolution of a substance in a mixture or matrix.
The dissolution rate can be affected by factors such as temperature, pH, and agitation.
In the med...read more
Q8. Which guidelines are follow for process validation
Guidelines for process validation include establishing process parameters, conducting process performance qualification, and ongoing monitoring.
Establish process parameters
Conduct process performance qualification
Ongoing monitoring
Document all validation activities
Ensure compliance with regulatory requirements
Consider risk management principles
Involve relevant stakeholders
Q9. area classification as per USFDA guidelines and ISO guidelines
Area classification is the process of determining the cleanliness level required for different areas in a pharmaceutical facility.
USFDA guidelines classify areas into four categories: A, B, C, and D based on the level of cleanliness required.
ISO guidelines classify areas into different classes such as ISO 5, ISO 7, and ISO 8 based on particle count limits.
The classification of areas is crucial for maintaining the quality of pharmaceutical products and ensuring compliance with...read more
Q10. Have you handled QMS
Yes, I have handled QMS (Quality Management System) in my previous role as Production Head.
Implemented and maintained QMS processes to ensure product quality and compliance with industry standards.
Developed and documented standard operating procedures (SOPs) for various production processes.
Conducted regular audits and inspections to identify areas for improvement and ensure adherence to QMS.
Implemented corrective and preventive actions to address non-conformities and improve...read more
Q11. What is filter integrity test and how to do.
Filter integrity test is a method to ensure the filter is functioning properly by testing its ability to retain particles of a certain size.
Filter integrity test is performed to verify the effectiveness of a filter in retaining particles of a specific size.
Common methods include bubble point test, diffusion test, pressure hold test, and water intrusion test.
The test results are compared against established acceptance criteria to determine if the filter is functioning properly...read more
Q12. How can perform PAO test. And concentration ratio
Performing PAO test involves measuring the concentration ratio of a substance in a solution.
Prepare a known concentration of the substance to be tested
Measure the absorbance of the solution at a specific wavelength using a spectrophotometer
Plot a standard curve using known concentrations of the substance
Calculate the concentration of the unknown sample using the standard curve
Concentration ratio can be calculated by dividing the concentration of the substance in the solution ...read more
Q13. Where to see this industry in Pharma role to Future Aspects?
The pharmaceutical industry is expected to see significant growth and advancements in the future.
The industry will continue to focus on research and development to discover new drugs and treatments.
Advancements in technology will play a crucial role in improving the quality and efficiency of pharmaceutical processes.
There will be an increased emphasis on personalized medicine and targeted therapies.
Regulatory requirements and quality standards will become more stringent to en...read more
Q14. What is the difference between mixture and solution
A mixture is a combination of two or more substances that are not chemically bonded, while a solution is a homogeneous mixture of two or more substances.
Mixture is not uniform throughout, while a solution is uniform throughout
In a mixture, the substances can be separated by physical means, while in a solution, the substances cannot be separated by physical means
Examples of mixtures include sand and water, while examples of solutions include saltwater and sugar water
Q15. How to handle the safety
To handle safety in production, it is important to follow safety protocols, conduct regular inspections, provide proper training, and maintain a clean and organized work environment.
Follow safety protocols and guidelines provided by the company and regulatory bodies.
Conduct regular inspections to identify and address any potential safety hazards.
Provide proper training to all employees on safety procedures and protocols.
Maintain a clean and organized work environment to minim...read more
Q16. tell more about ur subjects u studies in semister
I studied subjects related to biology, chemistry, and data analysis in the semester.
Biology: focused on genetics, cell biology, and ecology
Chemistry: covered organic and inorganic chemistry principles
Data analysis: learned statistical methods and data interpretation
Q17. How can calculate HVAC efficiency
HVAC efficiency can be calculated by dividing the useful output by the total input.
Calculate the useful output of the HVAC system, such as the amount of heating or cooling provided to the space.
Determine the total input of the HVAC system, including the energy consumed by the system.
Divide the useful output by the total input to get the efficiency percentage.
Efficiency (%) = (Useful Output / Total Input) * 100
For example, if a HVAC system provides 10,000 BTUs of cooling while...read more
Q18. what is oos ?and example of it
OOS stands for Out of Specification. It refers to test results that fall outside the specified limits.
OOS results can indicate a potential issue with the testing process or the quality of the product.
Examples of OOS include a drug potency test result that is lower than the specified limit or a food sample that exceeds the allowed microbial count.
OOS results require investigation to determine the cause and may lead to product rejection or retesting.
Q19. What is ALCOA ?
ALCOA is an acronym that stands for Attributable, Legible, Contemporaneous, Original, and Accurate.
ALCOA is a set of principles used in the pharmaceutical industry to ensure data integrity.
Attributable means that all data should be traceable to the person who generated it.
Legible means that the data should be clear and easy to read.
Contemporaneous means that the data should be recorded at the time of the activity.
Original means that the data should be the first recording of t...read more
Q20. In emercy swich vacation in form
The question is unclear and seems to contain a typo.
The question is not clear and may contain a typo.
It is difficult to provide a descriptive answer without understanding the question properly.
Please clarify the question or provide more context.
Q21. what is oot what is QMS
Oot stands for out of tolerance and QMS stands for Quality Management System.
Oot refers to a situation where a measurement or result falls outside the acceptable range of values.
QMS is a set of policies, processes, and procedures implemented by an organization to ensure quality in its products or services.
Examples of QMS include ISO 9001 certification and Six Sigma methodologies.
Q22. What is process validation
Process validation is the documented evidence that a process is consistently producing a product that meets predetermined specifications and quality attributes.
Process validation is a critical component of quality assurance in manufacturing.
It involves establishing documented evidence that a process is capable of consistently producing a product that meets predetermined specifications and quality attributes.
Process validation typically involves three stages: process design, p...read more
Q23. What is area qualifications
Area qualifications refer to the specific skills and knowledge required for a particular job or industry.
Area qualifications are often listed in job postings and include both technical and soft skills.
Examples of area qualifications for a software developer may include proficiency in programming languages, knowledge of software development methodologies, and strong problem-solving skills.
Area qualifications may also include certifications or licenses required for certain prof...read more
Q24. What is the role of Medicine in future.
Medicine will play a crucial role in the future by advancing technology, personalized treatments, and preventive care.
Advancement in technology will revolutionize healthcare delivery and improve patient outcomes.
Personalized treatments based on genetic profiling and precision medicine will become more common.
Preventive care will be emphasized to reduce the burden of chronic diseases.
Telemedicine and remote monitoring will enable better access to healthcare services.
Artificial...read more
Q25. What is DX coil
DX coil is a type of coil used in air conditioning systems to transfer heat between the indoor and outdoor units.
DX coil stands for Direct Expansion coil
It is a key component in air conditioning systems
DX coils are used to transfer heat between the refrigerant and the air being circulated in the system
They are commonly found in split air conditioning systems
Q26. How you select linearity levl
Linearity level is selected based on the expected range of the assay and the desired accuracy.
Consider the expected range of the assay
Determine the desired accuracy
Select a linearity level that covers the expected range and provides the desired accuracy
Verify linearity using a linearity study
Adjust linearity level if necessary
Q27. Class ISO 7 partical count
ISO 7 particle count refers to the cleanliness level of air in a controlled environment.
ISO 7 classifies air cleanliness based on the number of particles per cubic meter.
Lower particle counts indicate cleaner air and higher particle counts indicate more contamination.
ISO 7 is commonly used in cleanrooms and controlled environments to maintain quality standards.
Example: ISO 7 particle count may be 10,000 particles per cubic meter.
Q28. Some reaction of organic chemistry?
Organic chemistry involves the study of compounds containing carbon, focusing on their structure, properties, and reactions.
Organic chemistry deals with the study of carbon-containing compounds.
Reactions in organic chemistry involve the breaking and forming of chemical bonds.
Common reactions include substitution, addition, elimination, and oxidation-reduction.
Examples of organic reactions include esterification, hydrolysis, and polymerization.
Q29. what is hplc and its principle
HPLC stands for High Performance Liquid Chromatography. It is a technique used to separate, identify, and quantify components in a mixture.
HPLC involves pumping a sample mixture through a column filled with a stationary phase, which separates the components based on their interactions with the stationary phase.
The separated components are detected as they exit the column, allowing for identification and quantification.
HPLC is commonly used in pharmaceutical, environmental, an...read more
Q30. Name reactions like aldol condensation
Aldol condensation is a reaction in organic chemistry where an enolate ion reacts with a carbonyl compound to form a beta-hydroxy carbonyl compound.
Enolate ion reacts with a carbonyl compound
Forms a beta-hydroxy carbonyl compound
Can be catalyzed by bases or acids
Examples include the Claisen-Schmidt condensation and the Cannizzaro reaction
Q31. Principal of HPLC and GC
HPLC and GC are analytical techniques used in chemistry to separate, identify, and quantify components in a mixture.
HPLC stands for High Performance Liquid Chromatography, which uses a liquid mobile phase to separate compounds based on their affinity for the stationary phase.
GC stands for Gas Chromatography, which uses a gas mobile phase to separate compounds based on their volatility.
Both techniques are commonly used in analytical chemistry for qualitative and quantitative a...read more
Q32. IPQA Batch release procedure
IPQA Batch release procedure involves ensuring quality standards are met before releasing a batch for distribution.
IPQA stands for In-Process Quality Assurance
Batch release procedure involves thorough inspection of the batch to ensure it meets quality standards
Documentation of all inspections and tests conducted during the batch release process
Approval from Quality Assurance team before releasing the batch for distribution
Q33. Name two organic reactions
Two examples of organic reactions are esterification and polymerization.
Esterification involves the reaction between an alcohol and a carboxylic acid to form an ester.
Polymerization is the process of combining monomers to form a polymer chain.
Other examples include oxidation, reduction, hydrolysis, and substitution reactions.
Q34. Reactor's cost analysis
Reactor's cost analysis involves evaluating all expenses related to the construction, operation, and maintenance of the reactor.
Consider initial construction costs including materials, labor, and equipment
Factor in ongoing operational expenses such as fuel, maintenance, and staffing
Include long-term costs like decommissioning and waste disposal
Compare costs with benefits to determine overall feasibility and profitability
Q35. Connections with referral
Having connections with referrals can help in getting opportunities and expanding network.
Referrals can provide insider information about job openings.
Connections can introduce you to key decision makers in companies.
Referrals can vouch for your skills and qualifications.
Networking with referrals can lead to new opportunities and collaborations.
Q36. PDA and Uv detector difference
PDA and UV detector are both used in HPLC analysis but differ in their detection mechanism.
PDA detector measures the entire UV-Vis spectrum of the eluent while UV detector measures at a specific wavelength.
PDA detector can provide more information about the sample while UV detector is more sensitive and specific.
PDA detector is more expensive than UV detector.
PDA detector is useful for detecting impurities while UV detector is useful for quantification.
PDA detector is commonl...read more
Q37. Project management steps
Project management steps involve initiation, planning, execution, monitoring and control, and closure.
Initiation involves defining the project and its objectives.
Planning involves creating a roadmap for the project, including timelines, budgets, and resources.
Execution involves carrying out the plan and completing the project deliverables.
Monitoring and control involves tracking progress and making adjustments as needed.
Closure involves wrapping up the project and evaluating ...read more
Q38. Troubleshooting on HPLC
Q39. Please sale a pan
Our pan is a versatile kitchen essential, perfect for cooking a variety of dishes with ease.
Highlight the durability and quality of the pan
Mention its non-stick coating for easy cooking and cleaning
Emphasize its versatility for cooking different types of dishes
Offer a special promotion or discount to entice the customer
Provide a demonstration or cooking tips to showcase its benefits
Q40. Type of coating gun
The type of coating gun used is an airless spray gun.
Airless spray guns use high pressure to atomize the coating material and provide a smooth finish.
They are commonly used for painting large surface areas quickly and efficiently.
Examples of airless spray gun brands include Graco, Wagner, and Titan.
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