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Piramal Pharma

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40+ Interview Questions and Answers

Updated 24 Aug 2024

Q1. What is the difference between discriminatory media & bio relevant media?

Ans.

Discriminatory media is biased towards certain groups while bio relevant media mimics the natural environment of cells.

  • Discriminatory media can be based on race, gender, or other factors that unfairly favor or disadvantage certain groups

  • Bio relevant media is designed to replicate the conditions that cells would experience in the body, such as temperature, pH, and nutrient levels

  • Discriminatory media can lead to inaccurate or incomplete research results, while bio relevant medi...read more

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Q2. How will you perform method precision for Related substances method?

Ans.

Method precision for related substances method is performed by analyzing multiple samples of known concentration and calculating the standard deviation.

  • Analyze multiple samples of known concentration

  • Calculate the standard deviation

  • Ensure the precision is within acceptable limits

  • Repeat the analysis to confirm the precision

  • Use appropriate statistical tools to analyze the data

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Q3. How you will improve the quality and productivity of products

Ans.

To improve the quality and productivity of products, I would implement various strategies such as implementing quality control measures, optimizing production processes, and fostering a culture of continuous improvement.

  • Implementing quality control measures to identify and rectify any defects or issues in the production process.

  • Optimizing production processes by streamlining workflows, eliminating bottlenecks, and implementing automation where applicable.

  • Investing in employee...read more

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Q4. What are the EU requirements for multimedia dissolution?

Ans.

EU requirements for multimedia dissolution

  • Multimedia dissolution testing is required for certain types of drug products in the EU

  • The requirements are outlined in the European Pharmacopoeia (EP)

  • The EP specifies the apparatus, dissolution medium, and testing conditions for multimedia dissolution

  • The acceptance criteria for dissolution testing are also provided in the EP

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Q5. What is GMP ?,what is change control system ?

Ans.

GMP stands for Good Manufacturing Practice. Change control system is a process to manage changes in a controlled manner.

  • GMP is a set of guidelines that ensure the quality and safety of pharmaceutical products.

  • It covers all aspects of production, from raw materials to finished products.

  • Change control system is a process to manage changes in a controlled manner.

  • It involves documenting and reviewing proposed changes, assessing their impact, and implementing them in a controlled ...read more

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Q6. How will you develop dissolution method?

Ans.

I will develop dissolution method by considering the drug properties, selecting appropriate media, and optimizing parameters.

  • Understand the drug properties and solubility

  • Select appropriate media based on pH and solubility

  • Optimize parameters such as agitation speed and temperature

  • Validate the method by testing for accuracy and precision

  • Consider regulatory guidelines and requirements

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Q7. 1. When system lose pressure then what are doing ? 2. How many types of Dissolution ?

Ans.

Answering questions related to system pressure and types of dissolution.

  • When a system loses pressure, it needs to be re-pressurized to maintain its functionality.

  • There are two types of dissolution: intrinsic and extrinsic.

  • Intrinsic dissolution refers to the dissolution of a pure substance, while extrinsic dissolution refers to the dissolution of a substance in a mixture or matrix.

  • The dissolution rate can be affected by factors such as temperature, pH, and agitation.

  • In the med...read more

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Q8. Which guidelines are follow for process validation

Ans.

Guidelines for process validation include establishing process parameters, conducting process performance qualification, and ongoing monitoring.

  • Establish process parameters

  • Conduct process performance qualification

  • Ongoing monitoring

  • Document all validation activities

  • Ensure compliance with regulatory requirements

  • Consider risk management principles

  • Involve relevant stakeholders

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Q9. area classification as per USFDA guidelines and ISO guidelines

Ans.

Area classification is the process of determining the cleanliness level required for different areas in a pharmaceutical facility.

  • USFDA guidelines classify areas into four categories: A, B, C, and D based on the level of cleanliness required.

  • ISO guidelines classify areas into different classes such as ISO 5, ISO 7, and ISO 8 based on particle count limits.

  • The classification of areas is crucial for maintaining the quality of pharmaceutical products and ensuring compliance with...read more

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Q10. Have you handled QMS

Ans.

Yes, I have handled QMS (Quality Management System) in my previous role as Production Head.

  • Implemented and maintained QMS processes to ensure product quality and compliance with industry standards.

  • Developed and documented standard operating procedures (SOPs) for various production processes.

  • Conducted regular audits and inspections to identify areas for improvement and ensure adherence to QMS.

  • Implemented corrective and preventive actions to address non-conformities and improve...read more

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Q11. What is filter integrity test and how to do.

Ans.

Filter integrity test is a method to ensure the filter is functioning properly by testing its ability to retain particles of a certain size.

  • Filter integrity test is performed to verify the effectiveness of a filter in retaining particles of a specific size.

  • Common methods include bubble point test, diffusion test, pressure hold test, and water intrusion test.

  • The test results are compared against established acceptance criteria to determine if the filter is functioning properly...read more

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Q12. How can perform PAO test. And concentration ratio

Ans.

Performing PAO test involves measuring the concentration ratio of a substance in a solution.

  • Prepare a known concentration of the substance to be tested

  • Measure the absorbance of the solution at a specific wavelength using a spectrophotometer

  • Plot a standard curve using known concentrations of the substance

  • Calculate the concentration of the unknown sample using the standard curve

  • Concentration ratio can be calculated by dividing the concentration of the substance in the solution ...read more

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Q13. Where to see this industry in Pharma role to Future Aspects?

Ans.

The pharmaceutical industry is expected to see significant growth and advancements in the future.

  • The industry will continue to focus on research and development to discover new drugs and treatments.

  • Advancements in technology will play a crucial role in improving the quality and efficiency of pharmaceutical processes.

  • There will be an increased emphasis on personalized medicine and targeted therapies.

  • Regulatory requirements and quality standards will become more stringent to en...read more

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Q14. What is the difference between mixture and solution

Ans.

A mixture is a combination of two or more substances that are not chemically bonded, while a solution is a homogeneous mixture of two or more substances.

  • Mixture is not uniform throughout, while a solution is uniform throughout

  • In a mixture, the substances can be separated by physical means, while in a solution, the substances cannot be separated by physical means

  • Examples of mixtures include sand and water, while examples of solutions include saltwater and sugar water

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Q15. How to handle the safety

Ans.

To handle safety in production, it is important to follow safety protocols, conduct regular inspections, provide proper training, and maintain a clean and organized work environment.

  • Follow safety protocols and guidelines provided by the company and regulatory bodies.

  • Conduct regular inspections to identify and address any potential safety hazards.

  • Provide proper training to all employees on safety procedures and protocols.

  • Maintain a clean and organized work environment to minim...read more

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Q16. tell more about ur subjects u studies in semister

Ans.

I studied subjects related to biology, chemistry, and data analysis in the semester.

  • Biology: focused on genetics, cell biology, and ecology

  • Chemistry: covered organic and inorganic chemistry principles

  • Data analysis: learned statistical methods and data interpretation

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Q17. How can calculate HVAC efficiency

Ans.

HVAC efficiency can be calculated by dividing the useful output by the total input.

  • Calculate the useful output of the HVAC system, such as the amount of heating or cooling provided to the space.

  • Determine the total input of the HVAC system, including the energy consumed by the system.

  • Divide the useful output by the total input to get the efficiency percentage.

  • Efficiency (%) = (Useful Output / Total Input) * 100

  • For example, if a HVAC system provides 10,000 BTUs of cooling while...read more

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Q18. what is oos ?and example of it

Ans.

OOS stands for Out of Specification. It refers to test results that fall outside the specified limits.

  • OOS results can indicate a potential issue with the testing process or the quality of the product.

  • Examples of OOS include a drug potency test result that is lower than the specified limit or a food sample that exceeds the allowed microbial count.

  • OOS results require investigation to determine the cause and may lead to product rejection or retesting.

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Q19. What is ALCOA ?

Ans.

ALCOA is an acronym that stands for Attributable, Legible, Contemporaneous, Original, and Accurate.

  • ALCOA is a set of principles used in the pharmaceutical industry to ensure data integrity.

  • Attributable means that all data should be traceable to the person who generated it.

  • Legible means that the data should be clear and easy to read.

  • Contemporaneous means that the data should be recorded at the time of the activity.

  • Original means that the data should be the first recording of t...read more

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Q20. In emercy swich vacation in form

Ans.

The question is unclear and seems to contain a typo.

  • The question is not clear and may contain a typo.

  • It is difficult to provide a descriptive answer without understanding the question properly.

  • Please clarify the question or provide more context.

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Q21. what is oot what is QMS

Ans.

Oot stands for out of tolerance and QMS stands for Quality Management System.

  • Oot refers to a situation where a measurement or result falls outside the acceptable range of values.

  • QMS is a set of policies, processes, and procedures implemented by an organization to ensure quality in its products or services.

  • Examples of QMS include ISO 9001 certification and Six Sigma methodologies.

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Q22. What is process validation

Ans.

Process validation is the documented evidence that a process is consistently producing a product that meets predetermined specifications and quality attributes.

  • Process validation is a critical component of quality assurance in manufacturing.

  • It involves establishing documented evidence that a process is capable of consistently producing a product that meets predetermined specifications and quality attributes.

  • Process validation typically involves three stages: process design, p...read more

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Q23. What is area qualifications

Ans.

Area qualifications refer to the specific skills and knowledge required for a particular job or industry.

  • Area qualifications are often listed in job postings and include both technical and soft skills.

  • Examples of area qualifications for a software developer may include proficiency in programming languages, knowledge of software development methodologies, and strong problem-solving skills.

  • Area qualifications may also include certifications or licenses required for certain prof...read more

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Q24. What is the role of Medicine in future.

Ans.

Medicine will play a crucial role in the future by advancing technology, personalized treatments, and preventive care.

  • Advancement in technology will revolutionize healthcare delivery and improve patient outcomes.

  • Personalized treatments based on genetic profiling and precision medicine will become more common.

  • Preventive care will be emphasized to reduce the burden of chronic diseases.

  • Telemedicine and remote monitoring will enable better access to healthcare services.

  • Artificial...read more

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Q25. What is DX coil

Ans.

DX coil is a type of coil used in air conditioning systems to transfer heat between the indoor and outdoor units.

  • DX coil stands for Direct Expansion coil

  • It is a key component in air conditioning systems

  • DX coils are used to transfer heat between the refrigerant and the air being circulated in the system

  • They are commonly found in split air conditioning systems

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Q26. How you select linearity levl

Ans.

Linearity level is selected based on the expected range of the assay and the desired accuracy.

  • Consider the expected range of the assay

  • Determine the desired accuracy

  • Select a linearity level that covers the expected range and provides the desired accuracy

  • Verify linearity using a linearity study

  • Adjust linearity level if necessary

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Q27. Class ISO 7 partical count

Ans.

ISO 7 particle count refers to the cleanliness level of air in a controlled environment.

  • ISO 7 classifies air cleanliness based on the number of particles per cubic meter.

  • Lower particle counts indicate cleaner air and higher particle counts indicate more contamination.

  • ISO 7 is commonly used in cleanrooms and controlled environments to maintain quality standards.

  • Example: ISO 7 particle count may be 10,000 particles per cubic meter.

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Q28. Some reaction of organic chemistry?

Ans.

Organic chemistry involves the study of compounds containing carbon, focusing on their structure, properties, and reactions.

  • Organic chemistry deals with the study of carbon-containing compounds.

  • Reactions in organic chemistry involve the breaking and forming of chemical bonds.

  • Common reactions include substitution, addition, elimination, and oxidation-reduction.

  • Examples of organic reactions include esterification, hydrolysis, and polymerization.

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Q29. what is hplc and its principle

Ans.

HPLC stands for High Performance Liquid Chromatography. It is a technique used to separate, identify, and quantify components in a mixture.

  • HPLC involves pumping a sample mixture through a column filled with a stationary phase, which separates the components based on their interactions with the stationary phase.

  • The separated components are detected as they exit the column, allowing for identification and quantification.

  • HPLC is commonly used in pharmaceutical, environmental, an...read more

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Q30. Name reactions like aldol condensation

Ans.

Aldol condensation is a reaction in organic chemistry where an enolate ion reacts with a carbonyl compound to form a beta-hydroxy carbonyl compound.

  • Enolate ion reacts with a carbonyl compound

  • Forms a beta-hydroxy carbonyl compound

  • Can be catalyzed by bases or acids

  • Examples include the Claisen-Schmidt condensation and the Cannizzaro reaction

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Q31. Principal of HPLC and GC

Ans.

HPLC and GC are analytical techniques used in chemistry to separate, identify, and quantify components in a mixture.

  • HPLC stands for High Performance Liquid Chromatography, which uses a liquid mobile phase to separate compounds based on their affinity for the stationary phase.

  • GC stands for Gas Chromatography, which uses a gas mobile phase to separate compounds based on their volatility.

  • Both techniques are commonly used in analytical chemistry for qualitative and quantitative a...read more

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Q32. IPQA Batch release procedure

Ans.

IPQA Batch release procedure involves ensuring quality standards are met before releasing a batch for distribution.

  • IPQA stands for In-Process Quality Assurance

  • Batch release procedure involves thorough inspection of the batch to ensure it meets quality standards

  • Documentation of all inspections and tests conducted during the batch release process

  • Approval from Quality Assurance team before releasing the batch for distribution

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Q33. Name two organic reactions

Ans.

Two examples of organic reactions are esterification and polymerization.

  • Esterification involves the reaction between an alcohol and a carboxylic acid to form an ester.

  • Polymerization is the process of combining monomers to form a polymer chain.

  • Other examples include oxidation, reduction, hydrolysis, and substitution reactions.

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Q34. Reactor's cost analysis

Ans.

Reactor's cost analysis involves evaluating all expenses related to the construction, operation, and maintenance of the reactor.

  • Consider initial construction costs including materials, labor, and equipment

  • Factor in ongoing operational expenses such as fuel, maintenance, and staffing

  • Include long-term costs like decommissioning and waste disposal

  • Compare costs with benefits to determine overall feasibility and profitability

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Q35. Connections with referral

Ans.

Having connections with referrals can help in getting opportunities and expanding network.

  • Referrals can provide insider information about job openings.

  • Connections can introduce you to key decision makers in companies.

  • Referrals can vouch for your skills and qualifications.

  • Networking with referrals can lead to new opportunities and collaborations.

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Q36. PDA and Uv detector difference

Ans.

PDA and UV detector are both used in HPLC analysis but differ in their detection mechanism.

  • PDA detector measures the entire UV-Vis spectrum of the eluent while UV detector measures at a specific wavelength.

  • PDA detector can provide more information about the sample while UV detector is more sensitive and specific.

  • PDA detector is more expensive than UV detector.

  • PDA detector is useful for detecting impurities while UV detector is useful for quantification.

  • PDA detector is commonl...read more

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Q37. Project management steps

Ans.

Project management steps involve initiation, planning, execution, monitoring and control, and closure.

  • Initiation involves defining the project and its objectives.

  • Planning involves creating a roadmap for the project, including timelines, budgets, and resources.

  • Execution involves carrying out the plan and completing the project deliverables.

  • Monitoring and control involves tracking progress and making adjustments as needed.

  • Closure involves wrapping up the project and evaluating ...read more

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Q38. Troubleshooting on HPLC

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Q39. Please sale a pan

Ans.

Our pan is a versatile kitchen essential, perfect for cooking a variety of dishes with ease.

  • Highlight the durability and quality of the pan

  • Mention its non-stick coating for easy cooking and cleaning

  • Emphasize its versatility for cooking different types of dishes

  • Offer a special promotion or discount to entice the customer

  • Provide a demonstration or cooking tips to showcase its benefits

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Q40. Type of coating gun

Ans.

The type of coating gun used is an airless spray gun.

  • Airless spray guns use high pressure to atomize the coating material and provide a smooth finish.

  • They are commonly used for painting large surface areas quickly and efficiently.

  • Examples of airless spray gun brands include Graco, Wagner, and Titan.

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