How do you calculate the similarity factor (recovery factor)?

Question

Accepted Answer

Similarity factor (recovery factor) is calculated to assess the similarity between two dissolution profiles.

Similarity factor is a measure of the closeness of two dissolution profiles.
It is calculated using the mean and standard deviation of the percent dissolved values at each time point.
The formula for similarity factor is SF = 50 * log((1 + (1/n) * Σ(|R-T|/R)) / (1 + (1/n) * Σ(|R-T|/T))), where R is the reference profile and T is the test profile.
A similarity factor value close to 100 indicates high similarity between the profiles.
For example, if the similarity factor is 90, it means the two profiles are 90% similar.

Accepted Answer

Recovery factor=(weight of standard first*area of standard second/weight of standard second*area of standard first)*100

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