1000+ Executive Interview Questions and Answers

RS method development for known drug product involves identifying and separating enantiomers.

• Identify the chiral center(s) in the drug molecule

• Choose a suitable chiral stationary phase (CSP) for separation

• Optimize mobile phase composition and flow rate

• Validate the method for accuracy, precision, and specificity

• Consider regulatory requirements for enantiomeric purity

• Examples: RS method development for ibuprofen, omeprazole, etc.

Peak purity is a measure of the homogeneity of a chromatographic peak and is calculated using spectral data.

• Peak purity is determined by comparing the spectral data of the peak at different wavelengths.

• A peak with high purity will have a consistent spectral pattern across all wavelengths.

• Peak purity can be calculated using software or manually by comparing the spectra.

• Peak purity is important in ensuring accurate quantification and identification of compounds in a sample.

• Exam...read more

The procedure of export and import in China as a country and manufacturer/exporter, and the challenge of finding accommodation in a different town.

• Export and import procedures in China involve documentation, customs clearance, and transportation logistics.

• As a manufacturer and exporter, understanding regulations, tariffs, and trade agreements is crucial.

• Finding accommodation in a different town can be challenging, requiring research and planning.

• Examples of export and import ...read more

Excel is a powerful tool for data analysis and management. Advanced Excel includes features like pivot tables, macros, and data validation.

• Excel is used for organizing and analyzing data.

• Basic Excel skills include creating spreadsheets, entering data, and using formulas.

• Advanced Excel skills include pivot tables, macros, and data validation.

• Pivot tables allow you to summarize and analyze large amounts of data.

• Macros automate repetitive tasks in Excel.

• Data validation ensures d...read more

The biological indicator used in autoclave validation at 115 C is Geobacillus stearothermophilus.

• Geobacillus stearothermophilus is a spore-forming bacterium that is highly resistant to heat and is commonly used as a biological indicator in autoclave validation.

• It is used to ensure that the autoclave is effectively sterilizing equipment and materials at the desired temperature and pressure.

• Other biological indicators, such as Bacillus atrophaeus, may be used for different temp...read more

The pH value decreases when acid is added and increases when alkali is added.

• Acids release hydrogen ions (H+) when dissolved in water, which increases the concentration of H+ ions and lowers the pH value.

• Alkalis release hydroxide ions (OH-) when dissolved in water, which decreases the concentration of H+ ions and raises the pH value.

• The pH scale ranges from 0 to 14, with 7 being neutral. Values below 7 are acidic, and values above 7 are alkaline.

• For example, adding lemon juic...read more

To handle failure during batch processing, implement error handling mechanisms, monitor the process, and have a backup plan.

• Implement error handling mechanisms such as exception handling and logging to capture and handle failures during batch processing.

• Monitor the batch process regularly to identify any failures or errors and take appropriate actions to resolve them.

• Have a backup plan in place to ensure that critical data is not lost or corrupted in case of a failure.

• Conside...read more

To maintain delivery boys, provide incentives, clear communication, and a supportive work environment. In critical situations, have contingency plans in place.

• Offer incentives such as bonuses or flexible schedules to keep delivery boys motivated and engaged.

• Maintain clear communication channels to ensure that delivery boys are aware of their responsibilities and any changes in operations.

• Create a supportive work environment by providing training, resources, and opportunities ...read more

There are several types of columns in HPLC, including C18, C8, phenyl, and more. Column selection depends on the analyte and separation goal.

• Common types of HPLC columns include C18, C8, phenyl, and more

• Column selection depends on the analyte and separation goal

• C18 columns are commonly used for hydrophobic compounds

• Phenyl columns are useful for separating aromatic compounds

• C8 columns are a good alternative to C18 for some applications

• Other factors to consider when selecting a...read more

Yes, I have 4 years of experience working in a clean room environment in the production department.

• I have experience working with clean room protocols and procedures.

• I am familiar with maintaining a sterile environment and following strict hygiene practices.

• I have experience working with specialized equipment and tools used in clean room environments.

• I am able to work efficiently and effectively in a clean room environment, ensuring high quality production standards are met.

We use a variety of sensors including temperature, pressure, humidity, and motion sensors.

• Temperature sensors are used to monitor the temperature of equipment and environments.

• Pressure sensors are used to measure pressure in systems such as pipelines and tanks.

• Humidity sensors are used to measure the amount of moisture in the air.

• Motion sensors are used to detect movement in areas where security is a concern.

• Other sensors we use include light sensors, proximity sensors, and g...read more

A major breakdown in a compression machine and how to solve it.

• Identify the cause of the breakdown

• Check for any damaged parts and replace them

• Perform regular maintenance to prevent future breakdowns

• Consult with a professional if necessary

System suitability criteria for RS and Assay method

• RS: resolution between critical pairs should be greater than 1.5

• Assay: accuracy, precision, linearity, range, specificity, LOD, LOQ

• Acceptance criteria should be predefined and met

• System suitability test should be performed before sample analysis

Caffeine is used in HPLC calibration tests to determine the accuracy and precision of the instrument.

• Caffeine is a common standard used in HPLC calibration tests because it is readily available, stable, and has a well-defined retention time.

• The tests involve injecting a known amount of caffeine into the HPLC system and measuring its retention time and peak area.

• The results are compared to established reference values to ensure the accuracy and precision of the instrument.

• Othe...read more

The total voltage across the batteries in a 120kVA UPS depends on the number and type of batteries used.

• The voltage of each battery depends on its type and capacity

• The number of batteries used in the UPS affects the total voltage

• For example, if the UPS uses 12V batteries, 10 batteries would be needed to achieve a total voltage of 120V

FFS machine stands for Form-Fill-Seal machine, which is a packaging machine used to form, fill, and seal products in various industries.

• FFS machine is commonly used in industries such as food and beverage, pharmaceuticals, and cosmetics.

• It is an automated machine that can produce packaging materials on-site.

• The machine forms a package from a flat roll of film, fills it with the product, and then seals it.

• FFS machines can handle different types of packaging materials, includin...read more

Changing companies can provide new opportunities for growth and development.

• To seek new challenges and experiences

• To advance career goals

• To improve work-life balance

• To escape a toxic work environment

• To pursue a passion or interest

• To increase salary or benefits

• To relocate to a new city or country

Consult with a supervisor to determine the best course of action.

• Consult with a supervisor or team leader for guidance.

• Consider the urgency of the situation and potential risks of using the product without proper filtration.

• Check if there are any alternative filters or ways to bypass the pre-filters temporarily.

• Communicate with relevant stakeholders about the issue and potential solutions.

• Document the decision-making process and actions taken for future reference.

SAP, WPS, and last mile can be used together to optimize supply chain management.

• SAP can be used for inventory management and tracking.

• WPS can be used for workforce management and scheduling.

• Last mile can be used for optimizing delivery routes and reducing transportation costs.

• Integrating these tools can lead to more efficient and cost-effective supply chain management.

• For example, SAP can provide real-time inventory data to WPS, allowing for more accurate scheduling of deliv...read more

The three media used in microbiology analysis without sterilization are selective media, differential media, and enrichment media.

• Selective media: These media contain specific nutrients or chemicals that inhibit the growth of certain microorganisms while allowing the growth of others. For example, MacConkey agar is a selective medium used to isolate and differentiate Gram-negative bacteria.

• Differential media: These media contain indicators that allow the differentiation of di...read more

To handle work pressure during month end, prioritize tasks, delegate work, take breaks, and communicate with team members.

• Prioritize tasks based on urgency and importance

• Delegate work to team members who have the necessary skills and capacity

• Take breaks to avoid burnout and maintain productivity

• Communicate with team members to ensure everyone is on the same page and working towards the same goals

• Use time management techniques such as the Pomodoro technique to stay focused and...read more

Calibration tests for dissolution involve using prednisone as a standard.

• Prednisone is used as a standard because it is a commonly used drug and has a known dissolution rate.

• Calibration tests ensure that the dissolution apparatus is functioning properly and producing accurate results.

• Tests may include checking the temperature, pH, and agitation rate of the dissolution medium.

• The results of calibration tests are used to adjust the apparatus and ensure that it meets regulatory ...read more

Contingent liabilities are recognized when it is probable that a liability will occur and the amount can be reasonably estimated.

• Contingent liabilities are recognized when it is probable that a liability will occur and the amount can be reasonably estimated.

• Probable cases are those where the occurrence of the liability is likely based on available evidence.

• Possible cases are those where the occurrence of the liability is more than remote but less than probable.

• Remote cases ar...read more

The impact of set values of parameters on product quality

• Set values of parameters can have a direct impact on product quality

• If the set values do not affect the product quality, it is considered non-impactful

• Examples of parameters that can affect product quality include temperature, pressure, and time

• Proper calibration and monitoring of parameters can ensure consistent product quality

Discrimination media in dissolution refers to the selective dissolution of certain components in a mixture.

• It occurs when certain components dissolve faster or slower than others due to differences in solubility or chemical properties.

• Examples include the dissolution of sugar in water, where sugar dissolves faster than other components like sand or salt.

• In pharmaceuticals, discrimination media can be used to test the dissolution rate of different drug formulations.

• It is impor...read more

Inheritance is a mechanism in which a new class inherits properties and behaviors from an existing class. Polymorphism allows objects of different classes to be treated as objects of a common superclass.

• Java 8 features include lambda expressions, functional interfaces, streams, and default methods.

• Stack is a data structure that follows the Last In First Out (LIFO) principle, while a queue follows the First In First Out (FIFO) principle.

• Enhanced for loop in Java is used to ite...read more

Small micro size columns are not used in daily routine analysis due to limitations in sample capacity and resolution.

• Small micro size columns have limited sample capacity, which may not be sufficient for routine analysis that requires larger sample volumes.

• These columns also have limited resolution, which may not be suitable for complex analyses that require high separation power.

• Using larger columns allows for higher sample throughput and better resolution, making them more ...read more